Reducing the time and expense of engineering PROTAC degraders remains a significant challenge in the pharmaceutical industry. A PROTAC is composed of an E3 ligase ligand (E3-L), a protein of interest ...

Sometimes, reading Python code just isn’t enough to see what’s really going on. You can stare at lines for hours and still miss how variables change, or why a bug keeps popping up. That’s where a ...

Water — lots of it — is a critical enabler for advanced chip architectures, lithography, and back-end packaging. It feeds the ultra-pure water loops that touch every wafer, sluicing heat out of tools ...

Google is testing more upgrades to Gemini Live’s floating interface before its launch. The upgrade now enables support for contextual cards within the floating interface. This will allow you to ...

This valuable manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S proteasome regulates proteasome gating. The evidence ...

Abstract: The increasing complexity of System-on-Chip (SoC) products has amplified the potential for design bugs, necessitating robust post-silicon validation to ensure system reliability.

aPfizer Research and Development, 1 Portland St, Cambridge, MA, 02139, USA bPfizer Research and Development, 280 Shennecossett Rd, Groton, CT, 06340, USA cPfizer ...

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AI-based coding has exploded in popularity on the promise that it will make developers’ jobs faster and easier. But AI coding has also resulted in something else: a vast increase in lines of code, and ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Allostery refers to the activity regulation of biological macromolecules originating ...