BMP, bone morphogenetic protein; BMPR, bone morphogenetic protein receptor; HAMP, hepcidin; HFE, hereditary hemochromatosis protein; HJV, hemojuvelin; Holo-Tf, holo ...

Saturation of TfR1 leads to the dissociation of Hfe and the binding of the alter to the TfR2, which in turn influences the binding of BMP6 to its receptors on the membrane. Increased liver iron ...

The clinical introduction of hepcidin25 (Hep25) has led to a more detailed understanding of its relationship with ferroportin (FP) and divalent metal transporter1 in primary iron overload syndromes ...

For people who need blood transfusions, iron can accumulate in the heart and liver, causing damage and sometimes death. Doctors often prescribe medications called chelators that bind to iron and ...

Patients with serum ferritin levels higher than 1000 μg/L show a 91% increased risk for any fracture, with a doubled risk for vertebral and humerus fractures compared with those without iron overload.

Patients with iron overload — serum ferritin > 1000 µg/L or a diagnosis of hemochromatosis or thalassemia — were 60% more likely to have an osteoporotic fracture during an up to 10-year follow-up than ...

Thalassemia is subdivided into α-thalassemia and β-thalassemia, depending on the underlying genetic mutation and affected globin-chain subunits within the hemoglobin tetramer. The α-thalassemias have ...