High-quality evidence is what we use to guide medical practice. The standard approach to generating this evidence — a series of clinical trials, each investigating one or two interventions in a single ...

The U.S. Food and Drug Administration (FDA) recently issued a draft guidance, “Master Protocols for Drug and Biological Product Development”, that echoes and builds on principles that the Agency ...

Novel trial designs like basket, umbrella, and platform trials enhance efficiency and reduce development timelines in precision medicine. Basket trials test a single therapy across different tumor ...

BRCA1-Associated Protein 1 and Enhancer of Zeste Homolog 2: Pathway Interaction and Therapeutic Intervention in Breast Cancer, Mesothelioma, and Lymphoma Early-phase clinical trials (EPCTs) have been ...

Proton therapy is becoming an established precision cancer treatment. Studies comparing outcomes of proton and X-ray therapy, however, are mostly retrospective clinical or in vitro cell studies — ...